保护素 (Protectins) 的生物合成
中文名称
通路描述
花生四烯酸 (DHA) 是鱼类油中主要的 Ï-3 多不饱和脂肪酸 (PUFA)，是保护素 (PDs) 的来源之一，后者是一类具有强大抗炎和促修复作用的特化促炎介质 (SPMs) (Molfino et al. 2017, Balas & Durand 2016)。从促炎二十烷酸（如前列腺素和血栓烷）的合成向促修复脂质素、resolvins 和 protectins 的转变是通过诱导 15-脂氧酶酶促实现的。保护素被鉴定为 (N)PD1 (N 表示在神经组织中产生时为神经保护素)，是通过 15-脂氧酶的作用然后酶促水解从 DHA 衍生而来的。阿司匹林也可触发异构体保护素 (AT-PD1) 的形成 (Serhan et al. 2015)。通过两个脂氧酶反应的序贯作用形成另一种保护素 (DX)。这些保护素生物合成的描述如下 (Balas & Durand 2016, Balas et al. 2014, Serhan et al. 2014, Serhan et al. 2015)。
英文描述
Biosynthesis of protectins Docosahexaenoic acid (DHA), a major Ï-3 polyunsaturated fatty acid (PUFA) found in fish oil is the source of protectins (PDs), one of the specialized proresolving mediators (SPMs) that show potent anti-inflammatory and pro-resolving actions (Molfino et al. 2017, Balas & Durand 2016). The switch from synthesis of pro-inflammatory eicosanoids, such as the prostaglandins and the thromboxanes, to the pro-resolving lipoxins, resolvins and protectins, occurs via induction of the 15-lipoxygenase enzyme.
Protectin, identified as (N)PD1 (N signifies neuroprotectin when produced in neural tissues) is derived from DHA through the actions of 15-lipoxygenase then enzymatic hydrolysis. Aspirin can also trigger the formation of epimeric protectin (AT-PD1) (Serhan et al. 2015). An additional protectin (DX) is formed through the sequential actions of two lipoxygenase reactions. The biosynthesis of these protectins is described here (Balas & Durand 2016, Balas et al. 2014, Serhan et al. 2014, Serhan et al. 2015).
Protectin, identified as (N)PD1 (N signifies neuroprotectin when produced in neural tissues) is derived from DHA through the actions of 15-lipoxygenase then enzymatic hydrolysis. Aspirin can also trigger the formation of epimeric protectin (AT-PD1) (Serhan et al. 2015). An additional protectin (DX) is formed through the sequential actions of two lipoxygenase reactions. The biosynthesis of these protectins is described here (Balas & Durand 2016, Balas et al. 2014, Serhan et al. 2014, Serhan et al. 2015).
所含基因
4 个基因