白细胞介素 -23信号通路
中文名称
通路描述
白细胞介素 -23（IL23）是一种异二聚体，由白细胞介素 -12亚基β（IL12B, IL-12p40）和白细胞介素 -23亚基α（IL23A, IL-23p19）组成，与IL12共享。IL23的功能受体由白细胞介素 -12受体亚基β-1（IL12RB1）和白细胞介素 -23受体（IL23R）组成，其中IL12RB1与IL12受体共享。IL23R主要表达于活化的记忆T细胞、自然杀伤细胞、单核细胞/巨噬细胞以及低水平表达于树突状细胞（DCs）。IL23主要由皮肤、肠道黏膜和肺等外周组织中活化的巨噬细胞和DCs分泌。IL23具有促炎作用，与多种自身免疫性炎症疾病相关，如结肠炎、胃炎、银屑病和关节炎。它在结构和功能上与IL-12相似，均能增加记忆T细胞产生和增殖的干扰素-γ（IFN-γ）水平，且IL-23都能诱导IL-17。IL23通过激活Janus激酶JAK2和TYK2，导致受体复合物磷酸化，从而形成信号转导和激活转录因子3（STAT3）和STAT4的结合位点，使其磷酸化。
英文描述
Interleukin-23 signaling Interleukin-23 (IL23) is a heterodimer of Interleukin-12 subunit beta (IL12B, IL-12p40), which is shared with IL12, and Interleukin-23 subunit alpha IL23A (IL-23p19) subunit. The functional receptor for IL23 consists of Interleukin-12 receptor subunit beta-1 (IL12RB1), which is shared with the IL12 receptor, and Interleukin-23 receptor (IL23R). IL23R is mainly expresed on activated memory T cells, Natural Killer cells, monocytes/macrophage and at low levels on dendritic cells (DCs). IL23 is mainly secreted by activated macrophages and DCs in peripheral tissues such as skin, intestinal mucosa and lung. IL23 is proinlflammatory and implicated in several autoimmune inflammatory disorders such as colitis, gastritis, psoriasis and arthritis. It is similar to IL-12 both in structure and its ability to memory T cells to increase interferon-γ (IFN-γ) production and proliferation, the ability of IL-23 to induce IL-17. IL23 activates the Janus kinases JAK2 and TYK2, resulting in phosphorylation of the receptor complex, which forms the docking sites for Signal transducer and activator of transcription 3 (STAT3) and STAT4 to bind and become phosphorylated.
所含基因
9 个基因