TPX2 激活 AURKA
中文名称
通路描述
TPX2 在中心体结合 AURKA，促进其活性构象形成及 T288 丝氨酸的自磷酸化。
英文描述
Loss of MECP2 binding ability to the NCoR/SMRT complex Missense mutations in the transcriptional repression domain of methyl-CpG-binding protein 2 (MECP2) can negatively affect binding of MECP2 to the nuclear receptor co-repressor (NCoR/SMRT) complex (Lyst et al. 2013, Ebert et al. 2013).
所含基因
6 个基因