MECP2 调节神经元受体和通道
中文名称
通路描述
直接受 MECP2 转录调节的受体包括谷氨酸受体 GRIA2 (Qiu et al. 2012)、NMDA 受体亚基 GRIN2A (Durand et al. 2012) 和 GRIN2B (Lee et al. 2008)、阿片受体 OPRK1 (Chahrour et al. 2008) 和 OPRM1 (Hwang et al. 2009, Hwang et al. 2010, Samaco et al. 2012)、GPRIN1 (Chahrour et al. 2008)、MET (Plummer et al. 2013) 和 NOTCH1 (Li et al. 2014)。由 MECP2 调节的通道/转运蛋白包括 TRPC3 (Li et al. 2012) 和 SLC2A3 (Chen et al. 2013)。MECP2 还调节 FKBP5 的转录，该蛋白参与谷皮质激素受体的转运 (Nuber et al. 2005, Urdinguio et al. 2008)，并涉及 SEMA3F (半胱胺素 3F) 在鼠嗅觉神经元中的表达调节 (Degano et al. 2009)。在斑马鱼中，Mecp2 通过直接刺激 Sema5b 和 Robo2 的转录参与感觉轴突导向 (Leong et al. 2015)。MECP2 可能通过调节蛋白酪氨酸磷酸酶 PTPN1 (Krishnan et al. 2015) 和 PTPN4 (Williamson et al. 2015) 的转录间接调节神经元受体酪氨酸激酶的信号转导。
英文描述
MECP2 regulates neuronal receptors and channels Receptors directly transcriptionally regulated by MECP2 include glutamate receptor GRIA2 (Qiu et al. 2012), NMDA receptor subunits GRIN2A (Durand et al. 2012) and GRIN2B (Lee et al. 2008), opioid receptors OPRK1 (Chahrour et al. 2008) and OPRM1 (Hwang et al. 2009, Hwang et al. 2010, Samaco et al. 2012), GPRIN1 (Chahrour et al. 2008), MET (Plummer et al. 2013), and NOTCH1 (Li et al. 2014). Channels/transporters regulated by MECP2 include TRPC3 (Li et al. 2012) and SLC2A3 (Chen et al. 2013). MECP2 also regulates transcription of FKBP5, involved in trafficking of glucocorticoid receptors (Nuber et al. 2005, Urdinguio et al. 2008) and is implicated in regulation of expression of SEMA3F (semaphorin 3F) in mouse olfactory neurons (Degano et al. 2009). In zebrafish, Mecp2 is implicated in sensory axon guidance by direct stimulation of transcription of Sema5b and Robo2 (Leong et al. 2015). MECP2 may indirectly regulate signaling by neuronal receptor tyrosine kinases by regulating transcription of protein tyrosine phosphatases, PTPN1 (Krishnan et al. 2015) and PTPN4 (Williamson et al. 2015).
所含基因
16 个基因