细胞粘附蛋白的凋亡裂解
中文名称
通路描述
凋亡细胞表现出紧密连接、粘附连接和桥粒的显著重排（Abreu et al., 2000）。在凋亡启动后，包括Desmoglein-3、Plakophilin-1和Desmoplakin在内的粘附分子超家族中的粘附连接蛋白特异性成员被 caspase 切割（Weiske et al., 2001）。裂解导致桥粒结构破坏，从而促进细胞圆化和中间丝系统的解体（Weiske et al., 2001）。
英文描述
BDNF activates NTRK2 (TRKB) signaling Signaling by the neurotrophin receptor tyrosine kinase NTRK2 (TRKB) can be activated by binding to brain-derived neurotrophic factor (BDNF), which functions as a ligand for NTRK2 (Soppet et al. 1991, Klein et al. 1991). Binding to BDNF triggers NTRK2 dimerization (Ohira et al. 2001) and trans-autophosphorylation of NTRK2 dimers on conserved tyrosine residues in the cytoplasmic tail of the receptor (Guiton et al. 1994, Minichiello et al. 1998, McCarty and Feinstein 1999). Phosphorylated tyrosine residues subsequently serve as docking sites for recruitment of effector proteins that trigger downstream signaling cascades.
所含基因
2 个基因