DPAn-3 衍生的保护素和 resolvins 的生物合成
中文名称
通路描述
多不饱和脂肪酸（PUFA）DPAn-3（cis-7,10,13,16,19-二十碳五烯酸）是二十二碳五烯酸（DHA）从二十碳五烯酸（EPA）生物合成的中间体，也是新型生物活性介质产生的前体。这里描述了从 DPAn-3 衍生的 resolvins 和 protectins 的生物合成（Dalli 等，2013；Hansen 等，2017；Vik 等，2017）。15-脂氧合酶将 DPAn-3 氧化为 17(S) 羟基过氧化物异构体，然后通过氧化、还原和水解反应的组合形成 resolvins 和 protectins（Dalli 等，2013）。DPAn-3 的产物基于 DHA 衍生的 resolvins 和 protectins（Serhan 等，2002）进行表征，并被证明具有与 DHA 衍生的 specialised proresolving mediators（SPMs）相似的强效全身抗炎和组织保护作用（Dalli 等，2013）。DPAn-3 的产物形成的生物合成途径可能与 DHA 衍生的 SPMs 相同（Dalli 等，2013）。
英文描述
Biosynthesis of DPAn-3-derived protectins and resolvins The polyunsaturated fatty acid (PUFA) Ï-3 cis-7,10,13,16,19-docosapentaenoic acid (DPAn-3) is an intermediate in the biosynthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA) and is also a precursor for the production of novel bioactive mediators. The proposed biosynthesis of resolvins and protectins derived from DPAn-3 is described here (Dalli et al. 2013, Hansen et al. 2017, Vik et al. 2017). 15-lipoxygenase oxygenates DPAn-3 to its 17(S) hydroperoxy epimer from which resolvins and protectins are formed via a combination of oxygenation, reduction and hydrolysis reactions (Dalli et al. 2013). The products of the Ï-3 isomer were characterised based on docosahexaenoic acid (DHA)-derived resolvins and protectins (Serhan et al. 2002) and were demonstrated to have similar potent systemic anti-inflammatory and tissue protective actions as DHA-derived specialised proresolving mediators (SPMs) (Dalli et al. 2013). The same biosynthetic route as DHA-derived SPMs is probably how DPAn-3 products are also formed (Dalli et al. 2013).
所含基因
2 个基因