激活的 NTRK2 信号通过 RAS
中文名称
通路描述
BDNF 或 NTF4 激活神经生长因子受体 NTRK2（TRKB）触发下游 RAS 信号传导。RAS 信号传导下游 NTRK2 激活的最佳机制是通过 SHC1 介导的 GRB2:SOS1 复合物招募，触发 SOS1 介导的 RAS 鸟苷酸交换，形成活性 RAS:GTP 复合物（Minichiello 等人 1998, McCarthy 和 Feinstein 1999, Yuen 和 Mobley 1999）。
英文描述
Activated NTRK2 signals through RAS Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream RAS signaling. The best studied mechanism for activation of RAS signaling downstream of NTRK2 is through SHC1-mediated recruitment of the GRB2:SOS1 complex, triggering SOS1-mediated guanine nucleotide exchange on RAS and formation of active RAS:GTP complexes (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999).
所含基因
4 个基因