组织再生中马里斯素共轭物的生物合成（MCTR）
中文名称
通路描述
炎症的解除由称为特殊抗炎介质（SPMs）的内源性介质执行。巨噬细胞在急性炎症反应中起核心作用，根据激活的巨噬细胞亚型，分别控制启动和解决阶段。参与解决的人类巨噬细胞产生一种称为组织再生中马里斯素共轭物的生物活性肽共轭介质家族（MCTR）。这些介质刺激人类吞噬功能，促进细菌感染的解决，反调节促炎介质的产生，并促进组织修复和再生（Dalli 等人 2016）。提出的生物合成途径如下。马里斯素环氧中间体 13(S),14(S)-环氧-MaR（13(S),14(S)-环氧-docosahexaenoic 酸）可通过 LTC4S 和 GSTM4 转化为 MCTR1（13(R)-谷胱甘肽基，14(S)-羟基-docosahexaenoic 酸）。MCTR1 可通过谷氨酰转移酶（GGT）转化为 MCTR2（13(R)-巯基甘氨酸基，14(S)-羟基-docosahexaenoic 酸）。最后，一种二肽酶可将 MCTR2 中的巯基甘氨酸基键水解，产生 MCTR3（13(R)-巯基，14(S)-羟基-docosahexaenoic 酸）（Dalli 等人 2016, Serhan 等人 2017）。
英文描述
Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Resolution of inflammation is carried out by endogenous mediators termed specialised proresolving mediators (SPMs). Macrophages are central to the acute inflammatory response, governing both initiation and resolution phases, depending on the macrophage subtype activated. Human macrophages involved in resolution produce a family of bioactive peptide-conjugated mediators called maresin conjugates in tissue regeneration (MCTR). These mediators stimulate human phagocytotic functions, promote the resolution of bacterial infections, counterregulate the production of proinflammatory mediators and promote tissue repair and regeneration (Dalli et al. 2016). The proposed biosynthetic pathway is as follows. The maresin epoxide intermediate 13(S),14(S)-epoxy-MaR (13(S),14(S)-epoxy-docosahexaenoic acid) can be converted to MCTR1 (13(R)-glutathionyl, 14(S)-hydroxy-docosahexaenoic acid) by LTC4S and GSTM4. MCTR1 can be converted to MCTR2 (13(R)-cysteinylglycinyl, 14(S)-hydroxy-docosahexaenoic acid) by γ-glutamyl transferase (GGT). Finally, a dipeptidase can cleave the cysteinyl-glycinyl bond of MCTR2 to give MCTR3 (13(R)-cysteinyl, 14(S)-hydroxy-docosahexaenoic acid) (Dalli et al. 2016, Serhan et al. 2017).
所含基因
2 个基因