组织再生中保护素和 resolvin 共轭物的生物合成（PCTR 和 RCTR）
中文名称
通路描述
激活的人类巨噬细胞和中性粒细胞能够产生 17 系列硫基共轭的特殊抗炎介质（SPMs），这些介质能够解决急性炎症并促进组织再生。docosahexaenoic 酸（DHA）是这些新型 SPMs 的来源，即组织再生中 resolvin 共轭物（RCTR）和组织再生中保护素共轭物（PCTR）。由于 PCTR 和 RCTR 共享提出的生物合成途径、结构特征和生物学作用，它们分别被称为与 DHA 衍生的保护素和 resolvin 相似的组织再生共轭物，并显示出强大的组织再生作用（Serhan 等人 2014）。PCTRs 和 RCTRs 提出的生物合成途径描述如下（Dalli 等人 2015, Serhan 等人 2017）。哺乳动物脂氧合酶主要在 S-立体化学中插入分子氧，因此 7 位和 17 位的羟基假定处于 S-构型。这些产物中的 R 含对映异构体也可能在炎症解决和组织再生中发挥生物学作用，但此处未描述。
英文描述
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) Activated human macrophages and PMNs are able to produce 17-series sulfido-conjugated specialised proresolving mediators (SPMs) that are able to resolve acute inflammation and promote tissue regeneration. The Ï-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is the source of these novel SPMs termed resolvin conjugates in tissue regeneration (RCTR) and protectin conjugates in tissue regeneration (PCTR). protectin conjugate in tissue regeneration PCTR and RCTR are thus named because they share proposed biosynthetic pathways, structural features, and biological actions with the DHA-derived protectins and resolvins (respectively) as well as displaying potent tissue-regenerative actions (Serhan et al. 2014).
The proposed biosynthetic pathways for PCTRs and RCTRs are described here (Dalli et al. 2015, Serhan et al. 2017). Mammalian lipoxygenases insert molecular oxygen predominantly in the S-stereochemistry, so the hydroxy groups at the 7- and 17-positions are presumed to be in the S-configuration. The R-containing diastereomers of these products may also possess biological activity in the resolution of inflammation and tissue regeneration but they are not described here.
The proposed biosynthetic pathways for PCTRs and RCTRs are described here (Dalli et al. 2015, Serhan et al. 2017). Mammalian lipoxygenases insert molecular oxygen predominantly in the S-stereochemistry, so the hydroxy groups at the 7- and 17-positions are presumed to be in the S-configuration. The R-containing diastereomers of these products may also possess biological activity in the resolution of inflammation and tissue regeneration but they are not described here.
所含基因
1 个基因