促红细胞生成素激活STAT5
中文名称
通路描述
促红细胞生成素激活STAT5。STAT5（STAT5A或STAT5B）直接结合EPOR磷酸化的细胞质基序，由JAK2和LYN磷酸化（Oda et al. 1998，推断自小鼠同源物，综述于Kuhrt和Wojchowski 2015）。磷酸化的STAT5随后从EPOR解离，二聚化并转运至细胞核，激活基因表达。
英文描述
Erythropoietin activates STAT5 STAT5 (STAT5A or STAT5B) directly binds the phosphorylated cytoplasmic domain of EPOR, where it is phosphorylated by JAK2 and LYN (Oda et al. 1998, inferred from mouse homologs, reviewed in Kuhrt and Wojchowski 2015). Phosphorylated STAT5 then dissociates from EPOR, dimerizes, and transits to the nucleus where it activates gene expression.
所含基因
7 个基因