促红细胞生成素激活RAS
中文名称
通路描述
促红细胞生成素激活RAS。RAS鸟苷酸交换因子SOS1和VAV1通过CRKL、SHC1和GRB2间接结合磷酸化的EPOR（Miura et al. 1994, Hanazono et al. 1996, Odai et al. 1997, Arai et al. 2001，综述于Kuhrt等人2015）。磷酸化的EPOR基序结合CRKL，随后被磷酸化（Arai et al. 2001）。磷酸化的CRKL结合SHC1，随后被磷酸化并分别结合GRB2:SOS1（Barber et al. 1997）或GRB2:VAV1（Hanazono et al. 1996）。SOS1和磷酸化的VAV1催化RAS上结合的GDP与GTP交换，即RAS:GDP转化为RAS:GTP。
英文描述
Erythropoietin activates RAS The RAS guanine nucleotide exchange factors SOS1 and VAV1 bind indirectly to the phosphorylated EPOR via CRKL, SHC1, and GRB2 (Miura et al. 1994, Hanazono et al. 1996, Odai et al. 1997, Arai et al. 2001, reviewed in Kuhrt et al. 2015) . The phosphorylated cytoplasmic domain of EPOR binds CRKL, which is then phosphorylated (Arai et al. 2001). Phosphorylated CRKL binds SHC1, which is then phosphorylated and binds either GRB2:SOS1 (Barber et al. 1997) or GRB2:VAV1 (Hanazono et al. 1996). SOS1 and phosphorylated VAV1 catalyze the exchange of GDP for GTP bound to RAS, that is, RAS:GDP is converted to RAS:GTP.
所含基因
10 个基因