激活的 NTRK2 信号通过 FRS2 和 FRS3
中文名称
通路描述
适配蛋白 FRS2 和 FRS3 均可与激活的 NTRK2 (TRKB) 受体胞质尾部结合，随后 NTRK2 介导 FRS2 和 FRS3 的磷酸化。NTRK2 通过 FRS3 的信号通路研究尚不充分 (Easton et al. 1999, Yuen and Mobley 1999, Dixon et al. 2006, Zeng et al. 2014)。已知的磷酸化 FRS2 已知能招募 GRB2 (可能与 SOS1 复合物) 和 PTPN11 (SHP2) 到激活的 NTRK2，从而增强 RAS 信号 (Easton et al. 1999, Easton 2006)。
英文描述
Activated NTRK2 signals through FRS2 and FRS3 Adapter proteins FRS2 and FRS3 can both bind to the cytoplasmic tail of activated NTRK2 (TRKB) receptor, which is followed by NTRK2-mediated phosphorylation of FRS2 and FRS3. NTRK2 signaling through FRS3 has been poorly characterized (Easton et al. 1999, Yuen and Mobley 1999, Dixon et al. 2006, Zeng et al. 2014). Phosphorylated FRS2 is known to recruit GRB2 (presumably in complex with SOS1) and PTPN11 (SHP2) to activated NTRK2, leading to augmentation of RAS signaling (Easton et al. 1999, Easton 2006).
所含基因
7 个基因