APC 截短突变体具有受损的AXIN结合
中文名称
通路描述
APC肿瘤抑制基因突变在结直肠癌和其他癌症中很常见，并聚集在基因的中央突变簇区域（MCR）（Miyoshi et al, 1992; Nagase and Nakamura, 1993; Dihlmann et al, 1999; 综述于Bienz和Clevers, 2000）。这些突变通常导致截短蛋白破坏降解复合物并导致WNT通路激活升高（综述于Polakis, 2000）。
英文描述
NGF-stimulated transcription NGF stimulation induces expression of a wide array of transcriptional targets. In rat PC12 cells, a common model for NGF signaling, stimulation with NGF causes cells to exit the cell cycle and undergo a differentiation program leading to neurite outgrowth. This program is driven by the expression of immediate early genes (IEGs), which frequently encode transcription factors regulating the activity of NGF-specific delayed response genes (reviewed in Sheng and Greenberg, 1990; Flavell and Grennberg, 2008; Santiago and Bashaw, 2014).
所含基因
37 个基因