NTRK2 激活 RAC1
中文名称
通路描述
DOCK3 介导的 RAC1 下游激活，由 NTRK2 介导的 BDNF 信号通路触发，在轴突生长和再生中发挥作用。DOCK3 可招募至细胞膜，通过与 NTRK 关联的 FYN 结合激活 RAC1（Namekata 等，2010）。或者，在 BDNF:NTRK2 复合物激活 RHOG 后，DOCK3 结合到 RHOG:GTP 复合物上，在 ELMO1 介导的方式下激活 RAC1（Namekata 等，2012）。
英文描述
TYSND1 cleaves peroxisomal proteins After proteins are imported into the peroxisome a subset of proteins are cleaved by the protease TYSND1 (Okumoto et al. 2011). Based onmutagenesis of human TYSND1 (Okumoto et al. 2011) and the homolog in Arabidopsis (Schuhmann et al. 2008), TYSND1 appears to be a trypsin-like serine protease containing a conserved histidine aspartate serine triad essential for catalysis. Mice lacking Tysnd1 have reduced peroxisomal localization of some peroxisomal enzymes and exhibit reduced beta-oxidation of fatty acids and metabolism of phytanic acid (Mizuno et al. 2013). Male mice lacking Tysnd1 are sterile due to sperm that lack acrosomal caps.
所含基因
7 个基因