RHOF GTP 酶循环
中文名称
通路描述
该通路目录 RHOF (RIF) GTP 酶激活蛋白 (GAPs) 和 RHOF 效应蛋白。RHOF GTP 酶被认为在没有 GEF 活性时以活性 GTP 结合状态存在 (Tian et al. 2017)。尚未显示任何 GDP 解离抑制剂 (GDIs) 与 RHOF 相互作用。RHOF 仅存在于脊椎动物中 (Gad and Aspenstrom 2010; Fan and Mellor 2012)。RHOF 调节细胞骨架动力学 (Gad and Aspenstrom 2010; Aspenstrom et al. 2014) 并促进纤毛和应力纤维的形成 (Fan and Mellor 2012)。RHOF 可能参与淋巴细胞微绒毛中的肌动蛋白重塑 (Fan and Mellor 2012)。在神经元中，RHOF 有助于树突棘的形成 (Fan and Mellor 2012)。
英文描述
RHOF GTPase cycle This pathway catalogues RHOF (RIF) GTPase activator proteins (GAPs) and RHOF effectors. RHOF GTPase is thought to exist in the active GTP-bound state in the absence of any GEF activity (Tian et al. 2017). No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOF. RHOF is only found in vertebrates (Gad and Aspenstrom 2010; Fan and Mellor 2012). RHOF regulates cytoskeletal dynamics (Gad and Aspenstrom 2010; Aspenstrom et al. 2014) and promotes the formation of filopodia and stress fibers (Fan and Mellor 2012). RHOF may be involved in actin remodelling in lymphocyte microvilli (Fan and Mellor 2012). In neurons, RHOF contributes to the formation of dendritic spines (Fan and Mellor 2012).
所含基因
42 个基因