N-糖基化前体（脂联糖脂连接寡糖，LLO）的生物合成及向新生蛋白质的转移
中文名称
通路描述
N-糖基化始于14步合成脂联糖脂连接寡糖（LLO）的过程，该寡糖由14个糖分子组成（2个核心GlcNAc、9个甘露糖和3个末端GlcNAc）。该途径在真核生物中高度保守，在许多原核生物和古菌中也存在相关途径。与N-糖基化前体合成相关的基因突变会导致一组称为先天性糖基化缺陷症（I型和II型）的多种疾病。这些疾病的表型反映了N-糖基化在发育过程中对蛋白质折叠和分泌途径中蛋白质性质的重要作用，以及对细胞间相互作用或发育时机的调控。
英文描述
Regulation of IFNA/IFNB signaling There are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation of JAK and STAT by SHP protein phosphatases, inhibition of STAT function in the nucleus by protein inhibitors of activated STATs (PIAS) proteins, inhibition of tyrosine kinase activity of JAKs by SOCS as well as inhibition of JAK and IFNAR2 interaction by UBP43 are few of the negative regulation mechanisms in controling type I IFN signaling.
所含基因
23 个基因