铁的吸收和转运
中文名称
通路描述
铁细胞间的转运由转铁蛋白介导。然而，铁也可以通过自身形式，或以血红素和铁螯合剂的形式进入和离开细胞。当通过主要途径（通过转铁蛋白内吞）进入细胞时，其目标不是细胞质中（仍 elusive）的螯合铁池，也不是溶酶体，而是线粒体，在那里合成血红素并组装铁硫簇（Kurz et al,2008, Hower et al 2009, Richardson et al 2010）。
英文描述
Iron uptake and transport The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).
所含基因
26 个基因