TRAF6 介导的 NF-kB 激活
中文名称
通路描述
TRAF6/TAK1 信号激活经典 IKK 复合物，导致 NF-kappaB 以及 MAPK 级联的激活，进而激活 AP-1。尽管 TRAF6/TAK1 已被涉及在类似受体（TLR）介导的细胞因子产生中，但这些分子在 RIG-I（DDX58）/MDA5（IFIH1）途径介导的 I 型干扰素诱导调节中的作用尚不清楚。根据 Yoshida 等人的研究，DDX58:MAVS 通路需要 TRAF6 和 MAP3K、MEKK1 来激活 NF-kappaB 和 MAP Kinases 以最优诱导 I 型干扰素。
英文描述
TRAF6 mediated NF-kB activation The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kappaB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I (DDX58)/MDA5 (IFIH1) pathway is largely unknown. According to the study done by Yoshida et al. the DDX58:MAVS pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kappaB and MAP Kinases for optimal induction of type I IFNs.
所含基因
24 个基因