FADD/RIP-1 介导的 NF-κB 激活，由 caspase-8 和 -10 介导
中文名称
通路描述
Fas 相关死亡结构域 (FADD) 和受体相互作用蛋白 1 (RIP1) 是含有死亡结构域的分子，它们与 MAVS (IPS-1) 的 C 端部分相互作用，并通过启动启动子 caspase (caspase-8 和 -10) 的激活来诱导 NF-κB。通常，caspase 参与凋亡和炎症，但也表现出非凋亡功能。这些非凋亡 caspase 功能涉及 NF-κB 的 prodomain 介导的激活。加工后的 caspase (caspase-8/10) 编码 DED (死亡执行结构域) 强烈激活 NF-κB。caspase 介导 NF-κB 激活的确切机制尚不清楚，但 caspase-8/10 的 prodomain 可能作为支架发挥作用，并允许与信号分子结合的其他信号复合物 (IKK 复合物) 的招募。
英文描述
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Fas-AssociatedDeathDomain (FADD) and receptor interacting protein 1 (RIP1) are death domain containing molecules that interact with the C-terminal portion of MAVS (IPS-1) and induce NF-kB through interaction and activation of initiator caspases (caspase-8 and -10). Caspases are usually involved in apoptosis and inflammation but they also exhibit nonapoptotic functions. These nonapoptotic caspase functions involve prodomain-mediated activation of NF-kB. Processed caspases (caspase-8/10) encoding the DED (death effector domain) strongly activate NF-kB. The exact mechanism by which caspases mediate NF-kB activation is unclear, but the prodomains of caspase-8/10 may act as a scaffolding and allow the recruitment of the IKK complex in association with other signaling molecules.
所含基因
12 个基因