RIP1 介导的 IKK 复合物招募
中文名称
通路描述
受体相互作用蛋白 1 (RIP1) 通过中间诱导 NFkB 通路中的 IKK 复合物来介导促炎细胞因子的激活 [Ea et al. 2006]。Poly(I-C) 处理刺激了人胚胎肾 HEK293 细胞中 FLAG 标签 TLR3 受体复合物招募 RIP1、TRAF6 和 TAK1 [Cusson-Hermance et al. 2005]。RIP1 对 TRIF 依赖的 IRF3 激活是必需的，该过程在 TRIF/TBK1/IKKi 依赖 manner 中发生 [Cusson-Hermance et al. 2005, Sato et al. 2003]。
英文描述
IKK complex recruitment mediated by RIP1 Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways [Ea et al. 2006]. Poly(I-C) treatment stimulated the recruitment of RIP1, TRAF6, and TAK1 to the TLR3 receptor complex in human embryonic kidney HEK293 transfected with FLAG-tagged TLR3 [Cusson-Hermance et al. 2005]. RIP1 was shown to be dispensable for TRIF-dependent activation of IRF3, which occurs in a TRIF/TBK1/IKKi-dependent manner [Cusson-Hermance et al. 2005, Sato et al. 2003]
所含基因
22 个基因