钼辅因子的生物合成
中文名称
通路描述
钼辅因子 (MoCo) 需要人类中的三种酶：硫氧化酶、黄嘌呤氧化酶和醛氧化酶。其合成途径高度保守，植物和细菌可以轻易使用人类酶。然而，细菌在前三步后发生分化，其最终 MoCo 与真核生物不同。植物和动物还发展了它们的 MoCo 的改进，这是它们黄嘌呤和醛氧化酶功能所必需的。这意味着，在人类中，我们在这两种酶上发现硫化的而不是脱硫化的钼辅因子 (Schwarz 2005; Schwarz, Mendel, Ribbe 2009)。
英文描述
Molybdenum cofactor biosynthesis Molybdenum cofactor (MoCo) is needed by three enzymes in humans: sulfite oxidase, xanthine oxidase and aldehyde oxidase. The pathway of its synthesis is so conserved that plants and bacteria can readily use human enzymes. Bacteria, however, diverge after the first three steps from this path and their final MoCo differs from that of the eukaryotes. Plants and animals have also developed a refinement of their MoCo which is needed for the function of their xanthine and aldehyde oxidases. This means, in humans we find sulfurated instead of desulfurated molybdenum cofactor on these two enzymes (Schwarz 2005; Schwarz, Mendel, Ribbe 2009).
所含基因
7 个基因