FLT3 信号转导
中文名称
通路描述
类 III 受体酪氨酸激酶家族成员 Feline McDonough Sarcoma-like 酪氨酸激酶（FLT3）（也称为 FLK2（胎儿肝脏酪氨酸激酶 2）、STK-1（干细胞酪氨酸激酶 1）或 CD135）参与造血祖细胞和树突状细胞的分化、增殖和存活。在 FLT3 配体（FL）结合后，受体形成二聚体并被磷酸化。因此，适配体和信号分子与活性受体结合，触发包括 PI3K/Akt 和 MAPK 级联在内的各种下游途径的激活（Grafone T et al. 2012）。
英文描述
FLT3 Signaling Feline McDonough Sarcoma-like tyrosine kinase (FLT3) (also known as FLK2 (fetal liver tyrosine kinase 2), STK-1 (stem cell tyrosine kinase 1) or CD135) is a member of the class III receptor tyrosine kinase family involved in the differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Upon FLT3 ligand (FL) binding, the receptor forms dimers and is phosphorylated. Consequently, adapter and signaling molecules bind with the active receptor and trigger the activation of various pathways downstream including PI3K/Akt and MAPK cascades (Grafone T et al. 2012).
所含基因
15 个基因