伴侣介导的自噬
中文名称
通路描述
与囊泡介导的巨噬自噬相反，伴侣介导的自噬选择性地将单个蛋白质靶向至溶酶体进行降解。伴侣基于识别基序结合细胞内蛋白质，并将它们从细胞质转运至溶酶体膜。随后，蛋白质被转运至腔内进行消化（Cuervo A M 等，2014；Kaushik S 等，2018）。
英文描述
Chaperone Mediated Autophagy In contrary to the vesicle-mediated macroautophagy, the chaperone mediated mechanism of autophagy selectively targets individual proteins to the lysosome for degradation. Chaperones bind intracellular proteins based on recognition motifs and transports them from the cytosol to the lysosomal membrane. Subsequently, the protein is translocated into the lumen for digestion (Cuervo A M et al. 2014, Kaushik S et al. 2018).
所含基因
13 个基因