FOXO介导的细胞死亡基因转录
中文名称
通路描述
FOXO转录因子促进多种促凋亡基因的表达，如FASLG（Brunet 等，1999；Ciechomska 等，2003；Chen 等，2013；Li 等，2015）、PINK1（Mei 等，2009；Sengupta 等，2011）、BCL2L11（BIM）（Gilley 等，2003；Urbich 等，2005；Chuang 等，2007；Hughes 等，2011；Chen 等，2013；Wang 等，2016）、BCL6（Tang 等，2002；Fernandez de Mattos 等，2004；Shore 等，2006）和BBC3（PUMA）（Dudgeon 等，2010；Hughes 等，2011；Liu 等，2015；Wu 等，2016；Liu 等，2017；Fitzwalter 等，2018）。FOXO介导的细胞死亡基因诱导在发育中很重要，例如在神经系统发育中，FOXO在NGF撤除时促进神经元死亡（Gilley 等，2003），并有助于FOXO因子的肿瘤抑制作用（Arimoto Ishida 等，2004）。FOXO1转录活性涉及肠神经系统（ENS）前体的细胞死亡。RET信号，该信号激活PI3K/AKT信号，导致FOXO介导的转录抑制，确保ENS前体的生存（Srinivasan 等，2005）。STK11（LKB1）基因的转录，编码丝氨酸/苏氨酸蛋白激酶STK11（也称为肝脏激酶B1），直接由FOXO3和FOXO4刺激，该基因调节多种细胞过程，包括凋亡（Lutzner 等，2012）。
英文描述
FOXO-mediated transcription of cell death genes FOXO transcription factors promote expression of several pro-apoptotic genes, such as FASLG (Brunet et al. 1999, Ciechomska et al. 2003, Chen et al. 2013, Li et al. 2015), PINK1 (Mei et al. 2009, Sengupta et al. 2011), BCL2L11 (BIM) (Gilley et al. 2003, Urbich et al. 2005, Chuang et al. 2007, Hughes et al. 2011, Chen et al. 2013, Wang et al. 2016), BCL6 (Tang et al. 2002, Fernandez de Mattos et al. 2004, Shore et al. 2006) and BBC3 (PUMA) (Dudgeon et al. 2010, Hughes et al. 2011, Liu et al. 2015, Wu et al. 2016, Liu et al. 2017, Fitzwalter et al. 2018). FOXO-mediated induction of cell death genes is important during development, for example during nervous system development, where FOXO promotes neuronal death upon NGF withdrawal (Gilley et al. 2003), and also contributes to the tumor-suppressive role of FOXO factors (Arimoto Ishida et al. 2004). FOXO1 transcriptional activity is implicated in the cell death of enteric nervous system (ENS) precursors. RET signaling, which activates PI3K/AKT signaling, leading to inhibition of FOXO mediated transcription, ensures survival of ENS precursors (Srinivasan et al. 2005).
Transcription of the STK11 (LKB1) gene, encoding Serine/threonine-protein kinase STK11 (also known as Liver kinase B1), which regulates diverse cellular processes, including apoptosis, is directly stimulated by FOXO3 and FOXO4 (Lutzner et al. 2012).
Transcription of the STK11 (LKB1) gene, encoding Serine/threonine-protein kinase STK11 (also known as Liver kinase B1), which regulates diverse cellular processes, including apoptosis, is directly stimulated by FOXO3 and FOXO4 (Lutzner et al. 2012).
所含基因
16 个基因