FOXO转录活性的乙酰化调节
中文名称
通路描述
氧化应激诱导 FOXO 转录因子发生乙酰化，改变 FOXO 转录因子对目标 DNA 序列的偏好。组蛋白去乙酰化酶 SIRT1 和 SIRT3 去乙酰化 FOXO 转录因子（Brunet et al. 2004, Daitoku et al. 2004, Motta et al. 2004, Dansen et al. 2009, Kim et al. 2010, Tseng et al. 2013, 综述：Hisahara et al. 2005）。乙酰化还可调节 FOXO 的定位，从而抵消磷酸化（Frescas et al. 2005, Bertaggia et al. 2012）。
英文描述
Regulation of FOXO transcriptional activity by acetylation Oxidative stress induces acetylation of FOXO transcription factors, which changes the preference of FOXO transcription factors for target DNA sequences. Histone deacetylases SIRT1 and SIRT3 deacetylate FOXO transcription factors (Brunet et al. 2004, Daitoku et al. 2004, Motta et al. 2004, Dansen et al. 2009, Kim et al. 2010, Tseng et al. 2013, reviewed by Hisahara et al. 2005).
Acetylation can also regulate FOXO localization, overriding phosphorylation (Frescas et al. 2005, Bertaggia et al. 2012).
Acetylation can also regulate FOXO localization, overriding phosphorylation (Frescas et al. 2005, Bertaggia et al. 2012).
所含基因
13 个基因