FOXO介导的细胞周期基因转录
中文名称
通路描述
FOXO 转录因子诱导表达几种基因，这些基因负调控不同细胞类型的增殖，例如红细胞前体细胞（Bakker et al. 2004, Wang et al. 2015）和大脑皮层神经上皮前体细胞（Seoane et al. 2004）。
FOXO1、FOXO3 和 FOXO4 直接刺激细胞周期依赖性激酶（CDK）抑制剂 CDKN1A（p21Cip1）的转录（Seoane et al. 2004, Tinkum et al. 2013）。FOXO 转录因子可与 SMAD2/3:SMAD4 复合物合作，在 TGF-β信号刺激下诱导 CDKN1A 的转录（Seoane et al. 2004）。
FOXO1、FOXO3 和 FOXO4 刺激 CDKN1B（p27Kip1）基因的转录，但尚未证明 FOXO 直接结合 CDKN1B 基因座（Dijkers et al. 2000, Medema et al. 2000, Lees et al. 2008）。
FOXO3 和 FOXO4，以及可能 FOXO1，直接刺激 GADD45A 基因的转录（Tran et al. 2002, Furukawa Hibi et al. 2002, Hughes et al. 2011, Sengupta et al. 2011, Ju et al. 2014）。
FOXO1、FOXO3 和 FOXO4 直接刺激 RBL2（p130）基因的转录，该蛋白参与维持静止（G0）状态（Kops et al. 2002, Chen et al. 2006）。
FOXO1 和 FOXO3 直接刺激 CCNG2 蛋白的转录，该蛋白为抗增殖蛋白（Martinez Gac et al. 2004, Chen et al. 2006）。FOXO3 可能还刺激 BTG1 蛋白的转录（Bakker et al. 2004, Bakker et al. 2007, Wang et al. 2015）。
FOXO1 和 FOXO3 直接刺激 CAV1（编码粘蛋白 1）基因的转录，该蛋白参与负调控生长因子受体信号及静止细胞表型的建立（van den Heuvel et al. 2005, Roy et al. 2008, Nho et al. 2013, Sisci et al. 2013）。
FOXO1 和 FOXO3 促进 KLF4 基因的转录，该基因编码 Krueppel-like 因子 4，抑制小鼠 B 细胞的增殖（Yusuf et al. 2008）。
FOXO1 与 p-2S-SMAD2/3:SMAD4 复合物合作，刺激 MSTN 基因的转录，该基因编码肌动蛋白激酶（myostatin），一种 TGF-β家族成员，刺激肌成纤维细胞的分化（Allen and Unterman 2007）。
FOXO1、FOXO3 和 FOXO4 直接刺激细胞周期依赖性激酶（CDK）抑制剂 CDKN1A（p21Cip1）的转录（Seoane et al. 2004, Tinkum et al. 2013）。FOXO 转录因子可与 SMAD2/3:SMAD4 复合物合作，在 TGF-β信号刺激下诱导 CDKN1A 的转录（Seoane et al. 2004）。
FOXO1、FOXO3 和 FOXO4 刺激 CDKN1B（p27Kip1）基因的转录，但尚未证明 FOXO 直接结合 CDKN1B 基因座（Dijkers et al. 2000, Medema et al. 2000, Lees et al. 2008）。
FOXO3 和 FOXO4，以及可能 FOXO1，直接刺激 GADD45A 基因的转录（Tran et al. 2002, Furukawa Hibi et al. 2002, Hughes et al. 2011, Sengupta et al. 2011, Ju et al. 2014）。
FOXO1、FOXO3 和 FOXO4 直接刺激 RBL2（p130）基因的转录，该蛋白参与维持静止（G0）状态（Kops et al. 2002, Chen et al. 2006）。
FOXO1 和 FOXO3 直接刺激 CCNG2 蛋白的转录，该蛋白为抗增殖蛋白（Martinez Gac et al. 2004, Chen et al. 2006）。FOXO3 可能还刺激 BTG1 蛋白的转录（Bakker et al. 2004, Bakker et al. 2007, Wang et al. 2015）。
FOXO1 和 FOXO3 直接刺激 CAV1（编码粘蛋白 1）基因的转录，该蛋白参与负调控生长因子受体信号及静止细胞表型的建立（van den Heuvel et al. 2005, Roy et al. 2008, Nho et al. 2013, Sisci et al. 2013）。
FOXO1 和 FOXO3 促进 KLF4 基因的转录，该基因编码 Krueppel-like 因子 4，抑制小鼠 B 细胞的增殖（Yusuf et al. 2008）。
FOXO1 与 p-2S-SMAD2/3:SMAD4 复合物合作，刺激 MSTN 基因的转录，该基因编码肌动蛋白激酶（myostatin），一种 TGF-β家族成员，刺激肌成纤维细胞的分化（Allen and Unterman 2007）。
英文描述
FOXO-mediated transcription of cell cycle genes FOXO transcription factors induce expression of several genes that negatively regulate proliferation of different cell types, such as erythroid progenitors (Bakker et al. 2004, Wang et al. 2015) and neuroepithelial progenitor cells in the telencephalon (Seoane et al. 2004).
Transcription of cyclin-dependent kinase (CDK) inhibitors CDKN1A (p21Cip1) is directly stimulated by FOXO1, FOXO3 and FOXO4 (Seoane et al. 2004, Tinkum et al. 2013). FOXO transcription factors can cooperate with the SMAD2/3:SMAD4 complex to induce CDKN1A transcription in response to TGF-beta signaling (Seoane et al. 2004).
FOXO transcription factors FOXO1, FOXO3 and FOXO4 stimulate transcription of the CDKN1B (p27Kip1) gene, but direct binding of FOXOs to the CDKN1B gene locus has not been demonstrated (Dijkers et al. 2000, Medema et al. 2000, Lees et al. 2008).
FOXO3 and FOXO4, and possibly FOXO1, directly stimulate transcription of the GADD45A gene (Tran et al. 2002, Furukawa Hibi et al. 2002, Hughes et al. 2011, Sengupta et al. 2011, Ju et al. 2014).
Transcription of the retinoblastoma family protein RBL2 (p130), involved in the maintenance of quiescent (G0) state, is directly stimulated by FOXO1, FOXO3 and FOXO4 (Kops et al. 2002, Chen et al. 2006).
Transcription of the anti-proliferative protein CCNG2 is directly stimulated by FOXO1 and FOXO3, and possibly FOXO4 (Martinez Gac et al. 2004, Chen et al. 2006). Transcription of the anti-proliferative protein BTG1 is directly stimulated by FOXO3 (Bakker et al. 2004, Bakker et al. 2007, Wang et al. 2015).
Transcription of CAV1, encoding caveolin-1, involved in negative regulation of growth factor receptor signaling and establishment of quiescent cell phenotype, is directly stimulated by FOXO1 and FOXO3 (van den Heuvel et al. 2005, Roy et al. 2008, Nho et al. 2013, Sisci et al. 2013).
FOXO1 and FOXO3 promote transcription of the KLF4 gene, encoding a transcription factor Krueppel-like factor 4, which inhibits proliferation of mouse B cells (Yusuf et al. 2008).
FOXO1, together with the p-2S-SMAD2/3:SMAD4 complex, stimulates transcription of the MSTN gene, encoding myostatin, a TGF-beta family member that stimulates differentiation of myoblasts (Allen and Unterman 2007).
Transcription of cyclin-dependent kinase (CDK) inhibitors CDKN1A (p21Cip1) is directly stimulated by FOXO1, FOXO3 and FOXO4 (Seoane et al. 2004, Tinkum et al. 2013). FOXO transcription factors can cooperate with the SMAD2/3:SMAD4 complex to induce CDKN1A transcription in response to TGF-beta signaling (Seoane et al. 2004).
FOXO transcription factors FOXO1, FOXO3 and FOXO4 stimulate transcription of the CDKN1B (p27Kip1) gene, but direct binding of FOXOs to the CDKN1B gene locus has not been demonstrated (Dijkers et al. 2000, Medema et al. 2000, Lees et al. 2008).
FOXO3 and FOXO4, and possibly FOXO1, directly stimulate transcription of the GADD45A gene (Tran et al. 2002, Furukawa Hibi et al. 2002, Hughes et al. 2011, Sengupta et al. 2011, Ju et al. 2014).
Transcription of the retinoblastoma family protein RBL2 (p130), involved in the maintenance of quiescent (G0) state, is directly stimulated by FOXO1, FOXO3 and FOXO4 (Kops et al. 2002, Chen et al. 2006).
Transcription of the anti-proliferative protein CCNG2 is directly stimulated by FOXO1 and FOXO3, and possibly FOXO4 (Martinez Gac et al. 2004, Chen et al. 2006). Transcription of the anti-proliferative protein BTG1 is directly stimulated by FOXO3 (Bakker et al. 2004, Bakker et al. 2007, Wang et al. 2015).
Transcription of CAV1, encoding caveolin-1, involved in negative regulation of growth factor receptor signaling and establishment of quiescent cell phenotype, is directly stimulated by FOXO1 and FOXO3 (van den Heuvel et al. 2005, Roy et al. 2008, Nho et al. 2013, Sisci et al. 2013).
FOXO1 and FOXO3 promote transcription of the KLF4 gene, encoding a transcription factor Krueppel-like factor 4, which inhibits proliferation of mouse B cells (Yusuf et al. 2008).
FOXO1, together with the p-2S-SMAD2/3:SMAD4 complex, stimulates transcription of the MSTN gene, encoding myostatin, a TGF-beta family member that stimulates differentiation of myoblasts (Allen and Unterman 2007).
所含基因
17 个基因