NR1H2 和 NR1H3 调节基因表达以控制胆汁酸稳态
中文名称
通路描述
肝脏 X 受体 NR1H3（LXRα）和 NR1H2（LXRβ）是受固醇调节的转录因子，在与它们的同源氧化固醇配体结合后被激活。除了诱导旨在减少细胞固醇负荷的遗传程序外，配体激活的 NR1H2 和 NR1H3 还调节控制胆汁酸合成、转运和代谢的基因的表达和活性，例如将疏水性胆汁酸转化为极性代谢物并随尿液排泄的胆汁酸葡糖醛酸化酶 UGT1A3（Verreault 等人 2006）
英文描述
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Liver X receptors NR1H3 (LXR alpha) and NR1H2 (LXR beta) are sterol-responsive transcription factors that become activated upon the engagement with their cognate oxysterol ligands. Besides inducing a genetic program aimed to reduce the cellular sterol load, ligand-activated NR1H2 & NR1H3 also modulate the expression and activity of genes controlling bile acid synthesis, transport and metabolism such as bile acid-glucuronidating enzyme UGT1A3 which converts hydrophobic bile acids into polar metabolites that can be excreted in the urine (Verreault M et al. 2006).
所含基因
9 个基因