凋亡复合体活性的调节
中文名称
通路描述
凋亡是一种受控的细胞死亡过程，必须严格调控以确保潜在危险的细胞被高效清除，同时使因环境条件暂时受压的细胞能够恢复并存活（Bratton SB 和 Salvesen GS 2010）。凋亡活性的调节缺陷与神经退行性疾病和癌症等病理状态的发生有关（Favaloro 等人 2012）。线粒体或内源性凋亡途径在多个步骤上受到调节，包括凋亡复合体的形成和 caspase-9 的激活
英文描述
Regulation of the apoptosome activity Apoptosis is a controlled process of cell death, which must be tightly regulated to ensure that potentially dangerous cells are efficiently removed, while cells that are transiently stressed by environmental conditions can recover and survive (Bratton SB & Salvesen GS 2010). Defects in the regulation of apoptosis have been associated with the pathogenesis of disease states such as neurodegeneration and cancer (Favaloro B et al. 2012). The mitochondrial or intrinsic apoptotic pathway is regulated at multiple steps, including apoptosome formation and caspaseâ9 activation.
所含基因
11 个基因