由于 p16INK4A 与 CDK4 结合缺陷而逃避原癌基因诱导的衰老
中文名称
通路描述
CDKN2A 基因中的错义突变和小插入或缺失（indels）导致 p16INK4A 氨基酸改变，损害其结合 CDK4 的能力，从而干扰 p16INK4A 介导的细胞衰老诱导，以应对致癌信号（Jones 等人 2007）。p16INK4A 的功能丧失突变也可通过干扰 p16INK4A 介导的 NFKB 信号抑制来促进癌症（Becker 等人 2005）
英文描述
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Missense mutations and small indels in the CDKN2A gene, which result in amino acid changes in p16INK4A that impair its ability to bind to CDK4, interfere with p16INK4A-mediated induction of cellular senescence in response to oncogenic signaling (Jones et al. 2007).
Loss-of-function mutations in p16INK4A can also contribute to cancer by interfering with p16INK4A-mediated inhibition of NFKB signaling (Becker et al. 2005).
Loss-of-function mutations in p16INK4A can also contribute to cancer by interfering with p16INK4A-mediated inhibition of NFKB signaling (Becker et al. 2005).
所含基因
1 个基因