p16INK4A 与 CDK4 和 CDK6 结合缺陷导致的氧化应激诱导衰老逃避
中文名称
通路描述
CDKN2A 基因中导致 p16INK4A 氨基酸改变或截短的错义突变和无义突变，分别使 p16INK4A 无法结合 CDK4 和 CDK6，干扰 p16INK4A 介导的针对氧化应激诱导的细胞衰老。
p16INK4A 的功能缺失突变也可通过干扰 p16INK4A 介导的 NFKB 信号抑制促进癌症发生。
p16INK4A 的功能缺失突变也可通过干扰 p16INK4A 介导的 NFKB 信号抑制促进癌症发生。
英文描述
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Missense and nonsense mutations in the CDKN2A gene that result in amino acid substitutions in p16INK4A or p16INK4A truncations, respectively, impairing its ability to bind to CDK4 and CDK6, interfere with p16INK4A-mediated induction of cellular senescence in response to oxidative stress (Chen 2000, Vurusaner et al. 2012).
Loss-of-function mutations in p16INK4A can also contribute to cancer by interfering with p16INK4A-mediated inhibition of NFKB signaling (Becker et al. 2005).
Loss-of-function mutations in p16INK4A can also contribute to cancer by interfering with p16INK4A-mediated inhibition of NFKB signaling (Becker et al. 2005).
所含基因
2 个基因