膜信号下游的雌激素依赖性核事件
中文名称
通路描述
虽然膜定位的雌激素受体刺激快速、转录无关的反应，如钙动员和改变纤维连接蛋白基质以影响细胞迁移等，但快速信号激活的通路最终也可能影响核事件。膜定位的ESR1下游激活的MAPK和PI3K/AKT通路有助于雌激素反应性细胞增殖和生存的变化，部分通过基因表达的变化（综述于Levin等人，2005；Lange等人，2007；Le Romancer等人，2011）。
英文描述
Estrogen-dependent nuclear events downstream of ESR-membrane signaling Although membrane-localized estrogen receptors stimulate rapid, transcription-independent responses such as calcium mobilization and alterations to the fibronectin matrix to affect cell migration, among others, the pathways activated by rapid signaling may also ultimately affect nuclear events. Activation of MAPK and PI3K/AKT pathways downstream of membrane-localized ESR1 contributes to estrogen-responsive changes in cellular proliferation and survival in part through changes in gene expression (reviewed in Levin et al, 2005; Lange et al, 2007; Le Romancer et al, 2011).
所含基因
24 个基因