吞噬体 - 溶酶体融合抑制
中文名称
通路描述
脂多糖（LAM）被运输到 Mtb 的外周细胞壁。当 Mtb 被吞噬细胞吞噬时，LAM 被释放到吞噬细胞膜中，并入吞噬体膜的脂质筏中，在那里它阻止吞噬体 - 溶酶体融合（Welin et al. 2008, Gaur et al. 2014）。其他被抑制的过程还包括细胞骨架蛋白冠蛋白 -1A 和融合介质溶酶体蛋白转运相关蛋白 33B（VPS33B）（Deghmane et al. 2007, Bach et al. 2008）。此外，Ras 相关蛋白（Rab5）效应物磷脂酰肌醇 3-磷酸（PI3P）也被酶解耗尽（Vergne et al. 2005）。
英文描述
Prevention of phagosomal-lysosomal fusion Lipoarabinomannan (LAM) is transported to Mtb's outer cell wall. When Mtb is interned by the phagocyte, LAM is shedded into the phagocyte's membrane, gets incorporated into lipid rafts of the phagosomal membrane, where it acts to prevent phagosomal-lysosomal fusion (Welin et al. 2008, Gaur et al. 2014). Other processes that get inhibited include the cytoskeletal protein coronin-1A and the fusion mediator vacuolar protein sorting-associated protein 33B (VPS33B) (Deghmane et al. 2007, Bach et al. 2008). Also the Ras-related protein (Rab5) effector phosphatidylinositol 3-phosphate (PI3P) gets enzymatically depleted (Vergne et al. 2005).
所含基因
9 个基因