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Blockage of phagosome acidification

Reactome ID: R-HSA-9636467

中文名称

吞噬体酸化受阻

通路描述

吞噬体的酸化是通过在吞噬体膜上插入ATPase来完成的,以准备与溶酶体融合。由于结核分枝杆菌(Mtb)干扰几种酸化机制,含有Mtb的吞噬体的pH值永远不会低于6.5(Queval et al. 2017)。
英文描述
Blockage of phagosome acidification Acidification of the phagosome occurs by insertion of ATPases into the phagosomal membrane in preparation for fusion with lysosomes. The pH of phagosomes containing Mtb never drops below 6.5 due to Mtb interfering with several acidification mechanisms (Queval et al. 2017).

所含基因

1 个基因