泛素化
中文名称
通路描述
当蛋白酶体降解错误折叠蛋白的能力有限时，消除变性蛋白的替代途径是通过形成泛素体（aggresomes）来实现的。泛素体的形成始于在微管组织中心（MTOC）借助驱动蛋白马达蛋白的帮助，将错误折叠蛋白转运后对其进行泛素化修饰。在 MTOC 处，货物被中间丝蛋白包裹形成泛素体。随后，该泛素体招募伴侣蛋白，导致其被自噬性消除（Garcia Mata R et al. 2002）。
英文描述
Aggrephagy When the capacity of the proteosome to degrade misfolded proteins is limited, the alternate route to eliminate denatured proteins is via forming aggresomes - a process known as aggrephagy. Aggresome formation starts with ubiquitination of misfolded proteins following transport to the microtubule-organizing center (MTOC) with the help of dynein motor proteins. At the MTOC the cargo is encapsulated with intermediate filament proteins to result in the aggresome. Subsequently, this aggresome recruits chaperones that result in its autophagic elimination (Garcia Mata R et al. 2002).
所含基因
40 个基因