从 Man9/8/7GlcNAc2 到 Man5GlcNAc2 的α-1,2-连接甘露糖残基的渐进性修剪
中文名称
通路描述
在 cis-Golgi 中，Man7、Man8 或 Man9 N-糖链被渐进性修剪为 Man5 N-糖链。该反应可由三种已知的甘露糖苷酶催化，这些酶在不同组织中表达且亲和力略有不同。这些酶以不同的顺序修剪甘露糖残基（Tremblay and Herscovics, 2000），但产生相同的输出，即 5 个甘露糖。文献中关于编码这些酶的基因的命名存在混淆：标准的 HGNC 符号为 MAN1A1、MAN1A2 和 MAN1C1，但 MAN1A2 在某些出版物中也被称为 MAN1B，而 MAN1B1 是作用于未折叠糖蛋白的 ERQC 区间的酶。此外，这些名称并不对应于这些酶优先修剪这三种甘露糖分支中的哪一个。
英文描述
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 In the cis-Golgi, Man7, Man8 or Man9 N-glycans are progressively trimmed to Man5 N-glycans. The reaction can be catalyzed by one of three known mannosidases, expressed in different tissues and with slightly different affinity. These enzymes trim the mannoses in a different order (Tremblay and Herscovics, 2000), but produce the same output with 5 mannoses.
A small confusion on the nomenclature of these genes coding for these enzymes is present in the literature: the standard HGNC symbols are MAN1A1, MAN1A2, MAN1C1, but MAN1A2 is also referred to as MAN1B in certain publications, while MAN1B1 is the enzyme acting in the ERQC compartment on unfolded glycoproteins. Moreover, the names do not correspond to a preference of these enzymes for which of the three mannose branches these trim first.
A small confusion on the nomenclature of these genes coding for these enzymes is present in the literature: the standard HGNC symbols are MAN1A1, MAN1A2, MAN1C1, but MAN1A2 is also referred to as MAN1B in certain publications, while MAN1B1 is the enzyme acting in the ERQC compartment on unfolded glycoproteins. Moreover, the names do not correspond to a preference of these enzymes for which of the three mannose branches these trim first.
所含基因
3 个基因