CD163 介导的抗炎反应
中文名称
通路描述
巨噬细胞中高表达膜蛋白 CD163 是组织对由胞内病原体感染（如麻风分枝杆菌或利什曼原虫）或急性或慢性炎症性疾病引起的炎症反应的特征。该分子的可溶性形式 sCD163 被认为是潜在的炎症生物标志物和治疗靶点；sCD163 是由肿瘤坏死因子 -α（TNF-α）切割酶 ADAM17 介导的 CD163 增加脱落形成的。sCD163 的生物功能尚不清楚，尽管已提出几种可能的功能：金黄色葡萄球菌的调理作用、T 细胞增殖的抑制以及肿瘤坏死因子样弱诱导凋亡（TWEAK）的抑制（Tran et al. 2005）。
英文描述
CD163 mediating an anti-inflammatory response High expression of the membrane protein CD163 in macrophages is a characteristic of tissues responding to inflammation elicited either by an intracellular pathogen infection (such as Mycobacterium leprae or Leishmania spp.) or due to an acute or chronic inflammatory disorder. The soluble form of this molecule, sCD163, is considered to be a potential inflammation biomarker and a therapeutic target; sCD163 is formed from the increased shedding of CD163 mediated by the tumor necrosis factor-α (TNF-α) cleaving enzyme, ADAM17 (Etzerodt & Moestrup 2013, Silva et al. 2017). The biological function of sCD163 is not yet clear, although several possible functions have been proposed: opsonization of Staphylococcus aureus, inhibition of T-cell proliferation and inhibition of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) (Tran et al. 2005).
所含基因
8 个基因