FCGR3A-mediated IL10 synthesis

FCGR3A-mediated IL10 synthesis Interleukin 10 (IL-10) is an important immunoregulatory cytokine produced by many cell populations; in macrophages it is induced after the stimulation of TLRs, Fcγ receptors or by the TLR-FcγR crosstalk (Vogelpoel et al. 2014 & Saninet al. 2015). Classically, its function is considered to be the limitation and termination of inflammatory responses and the regulation of differentiation of several immune cells (Asadullah et al. 2003). There is increasing evidence of the role of IL-10 in parasite infection outcomes either as a protective or a pathological mediator (Asadullah et al. 2003). In the context of the parasitic disease cutaneous leishmaniasis, Leishmania amastigotes opsonized by IgG induce IL-10 response through FcγRs, which in turn supresses the killing mechanisms in phagocytic cells. (Chu et al. 2010).