FCGR3A 介导的吞噬作用

中文名称

FCGR3A 介导的吞噬作用

通路描述

Fcγ受体（FCGRs）已被报道促进利什曼原虫的内化，特别是在其原虫形式时（Ueno et al. 2012）。在已建立感染或既往感染宿主中细胞间传播后，宿主产生的 IgG 覆盖利什曼原虫原虫的表面，使其通过 FCGRs 更易被吞噬（Polando et al. 2013）。

传统上，通过 FCGRs 的吞噬作用与随后激活 Rac GTP 酶和 Cdc42 有关，这些酶进而激活吞噬细胞的 NADPH 氧化酶，促进杀伤机制的激活（Ueno et al. 2012）。

英文描述

FCGR3A-mediated phagocytosis The Fc gamma receptors (FCGRs) have been reported to facilitate Leishmania internalization, especially when in its amastigote form (Ueno et al. 2012). Following cell-to-cell propagation within an established infection or reinfection of a previously infected host, the IgG produced by the host covers the surface of Leishmania amastigote parasites, making them more susceptible to phagocytosis through FCGRs (Polando et al. 2013).

Classically, phagocytosis via FCGRs has been associated with the subsequent activation of Rac GTPases and Cdc42 which in turn activate the phagocyte's NADPH oxidase, contributing to the activation of killing mechanisms (Ueno et al. 2012).

所含基因

73 个基因

ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR3A FGR FYN HCK IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGKC IGKVA18 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV LPG1G2 LYN MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD PTK2 RAC1 SRC SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WASP WIPF1 WIPF2 WIPF3 YES1