磷酸化跨膜、胞外和激酶结构域 KIT 突变体的信号传导
中文名称
通路描述
观察到激活的跨膜、胞外和激酶结构域 KIT 突变体下游存在 PI3K/mTOR、RAS/MAPK 和 STAT 信号通路的激活，尽管在所有情况下下游信号传导的研究尚不充分。这些通路的激活有助于细胞增殖、避免凋亡以及细胞骨架组织（Dunesing 等，2004; Bauer 等，2007; Chi 等，2010; Bosbach 等，2017; 综述于 Lennartsson 和 Roonstrand，2012; Corless 等，2011）。
英文描述
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Activation of the PI3K/mTOR, RAS/MAPK and STAT signaling pathways has been observed downstream of activated extracellular, juxtamembrane and kinase domain mutants of KIT, although downstream signaling has not been studied in great detail in all cases. Activation of these pathways contributes to cellular proliferation, avoidance of apoptosis, and actin cytoskeletal organization (Dunesing et al, 2004; Bauer et al, 2007; Chi et al, 2010; Bosbach et al, 2017; reviewed in Lennartsson and Roonstrand, 2012; Corless et al, 2011).
所含基因
15 个基因