WNT5:FZD7介导的利什曼原虫抑制
中文名称
通路描述
Wnt-5a (WNT5) 是一种对微生物感染（包括利什曼原虫病）反应高度特异且受调控的基因（Blumenthal et al. 2006, Pereira et al. 2008 & Ljungberg et al. 2019），似乎参与在主要宿主巨噬细胞内抑制寄生虫载量的机制（Chakraborty et al. 2017）。此外，WNT5 是人体内巨噬细胞中高度响应基因，存在于慢性疾病中，如类风湿性关节炎（Sen et al. 2000）、癌症（Pukrop et al. 2006）、动脉粥样硬化（Christman et al. 2008）和肥胖症（Ouchi et al. 2010 & Ljungberg et al. 2019）。Frizzled-7 (FZD7) 作为 WNT5 的受体，在结合后参与启动非经典 WNT 通路，最终导致细胞骨架重新调整以允许平面细胞极性（PCP）过程的发生（Ljungberg et al. 2019）。WNT5:FZD7 非经典信号通路的激活正在研究其参与炎症反应中的作用（Shao et al. 2016）。用重组 Wnt5a 处理 RAW264.7 巨噬细胞诱导了 NADPH 氧化酶介导的 ROS 产生，这已被建议有助于巨噬细胞对 L. donovani 的控制。因此，详细理解 WNT 信号网络如何定义宿主对感染的反应对于识别潜在靶点（Ljungberg et al. 2019）可能很重要。
英文描述
WNT5:FZD7-mediated leishmania damping Wnt-5a (WNT5) is known for being a highly specific regulated gene in response to microbial infection (Blumenthal et al. 2006, Pereira et al. 2008 & Ljungberg et al. 2019) including leishmaniasis (Chakraborty et al. 2017), where it seems to be involve in mechanisms that dampen the parasite load within main host macrophages (Chakraborty et al. 2017). In addition, WNT5 is a highly responsive gene in human macrophages present in chronic diseases such as rheumatoid arthritis (Sen et al. 2000), cancer (Pukrop et al. 2006), atherosclerosis (Christman et al. 2008) and obesity (Ouchi et al. 2010 & Ljungberg et al. 2019).
Frizzled-7 (FZD7) acts as a receptor of WNT5 which, upon binding, is implicated in the initiation of the non-canonical WNT pathway that ends up in the re-accommodation of the cytoskeleton to allow a process called planar cell polarity (PCP) (Ljungberg et al. 2019). The activation of the WNT5:FZD7 non-canonical signalling cascade that drives PCP is being studied for its involvement in inflammatory responses (Shao et al. 2016). Treatment of RAW264.7 macrophages with recombinant Wnt5a induced NADPH oxidase-mediated ROS production, which has been suggested to contribute to the macrophage control of L. donovani. Consequently, detailed understanding of how WNT signaling network defines host responses to infection could be important to identify potential targets (Ljungberg et al. 2019).
Frizzled-7 (FZD7) acts as a receptor of WNT5 which, upon binding, is implicated in the initiation of the non-canonical WNT pathway that ends up in the re-accommodation of the cytoskeleton to allow a process called planar cell polarity (PCP) (Ljungberg et al. 2019). The activation of the WNT5:FZD7 non-canonical signalling cascade that drives PCP is being studied for its involvement in inflammatory responses (Shao et al. 2016). Treatment of RAW264.7 macrophages with recombinant Wnt5a induced NADPH oxidase-mediated ROS production, which has been suggested to contribute to the macrophage control of L. donovani. Consequently, detailed understanding of how WNT signaling network defines host responses to infection could be important to identify potential targets (Ljungberg et al. 2019).
所含基因
9 个基因