ERBB4信号下调
中文名称
通路描述
ERBB4 C-尾中的WW-domain结合基序在ERBB4受体信号下调中起重要作用，使完整的ERBB4、ERBB4 m80和ERBB4 s80与NEDD4家族E3泛素连接酶WWP1和ITCH相互作用。WWP1和ITCH与完整ERBB4的相互作用不依赖于受体激活和磷酸化。WWP1和ITCH泛素连接酶的结合导致ERBB4及其切割产物泛素化，并通过蛋白酶体和溶酶体途径进行降解（Omerovic et al. 2007, Feng et al. 2009）。此外，ERBB4 JM-A CYT-1等位基因的s80切割产物是NEDD4泛素连接酶的靶标。NEDD4通过其PIK3R1相互作用位点结合ERBB4 JM-A CYT-1 s80（ERBB4jmAcyt1s80），介导ERBB4jmAcyt1s80的泛素化，从而减少ERBB4jmAcyt1s80到达细胞核的量（Zeng et al. 2009）。
英文描述
Replication of the SARS-CoV-1 genome The plus strand RNA genome of the human SARS coronavirus 1 (SARS-CoV-1) is replicated by the viral replication-transcription complex (RTC) composed of nonstructural proteins nsp3-nsp16, encoded by open reading frames ORF1a and ORF1b. Two RTC proteins, nsp8 and nsp12, possess 5'-3' RNA-dependent RNA polymerase activity. nsp12 is the main RNA polymerase, while nsp8 is thought to act as an RNA primase. nsp14 acts as a 3'-5' exonuclease, increasing the fidelity of the RTC. nsp14 also has the RNA capping activity and, in concert with nsp16, it caps viral plus strand and minus strand genomic and subgenomic RNAs, which confers stability to viral RNAs by enabling them to escape interferon-mediated innate immune responses of the host. nsp13 is an RNA helicase which is thought to melt secondary structures in the genomic RNA during replication and transcription. The plus strand genomic RNA is first used to synthesize the minus strand genomic RNA complement, which is subsequently used as a template for synthesis of plus strand viral RNA genomes that are packaged into mature virions. For review, please refer to Yang and Leibowitz 2015, Snijder et al. 2016, Fung and Liu 2019.
所含基因
4 个基因