结构蛋白翻译
中文名称
通路描述
SARS-CoV-1 mRNA 根据核糖体扫描模型翻译。病毒 mRNA 被加帽和多聚腺苷酸化，5'和3'两端均含有非翻译序列。结构蛋白由聚合酶/复制酶基因后的 mRNA 2（刺突蛋白）、3、4（包膜蛋白）、5（膜蛋白）和 9 编码。mRNA 3 和 9 为双顺反子，蛋白 3a 和 9a（核衣壳蛋白）在病毒组装和结构中有功能。翻译发生在内质网中，但 9a 由胞质游离核糖体翻译（Fung 和 Liu，2019）。
英文描述
Translation of Structural Proteins SARS-CoV-1 mRNA is translated according to the ribosomal scanning model. Virus mRNA is capped and polyadenylated, with regions of nontranslated sequences on both the 5' and 3' ends. Structural proteins are encoded after the polymerase/replicase genes by mRNAs 2 (Spike protein), 3, 4 (Envelope protein), 5 (Membrane protein), and 9. mRNA 3 and 9 are bicistronic, the proteins 3a and 9a (Nucleocapsid protein) having functions in virus assembly and structure. Translation happens in the ER with the exception of 9a which is translated by cytosolic free ribosomes (Fung and Liu, 2019).
所含基因
1 个基因