RIPK1 介导的调控坏死中微生物的调节
中文名称
通路描述
受体相互作用丝氨酸/苏氨酸蛋白激酶（RIP）激酶 RIPK1 和 RIPK3 的激活协调一种免疫原性的程序性细胞死亡形式，即调控坏死或坏死性凋亡（Upton JW 等 2017）。这种坏死形式通过细胞死亡相关分子模式（DAMPs）的释放导致宿主产生抗病毒炎症（Nailwal H & Ka-Ming Chan F 2019; Upton JW 等 2017）。微生物病原体能够通过不同的触发器和途径调节宿主调控坏死。宿主细胞死亡促进和抑制因微生物类型、毒力和表型而异，并取决于微生物类型（Upton JW 等 2010, 2012, 2017; Jaclyn S Pearson JS 等 2017; Petrie EJ 等 2019; Fletcher-Etherington A 等 2020; Nailwal H & Ka-Ming Chan F 2019;）
英文描述
Microbial modulation of RIPK1-mediated regulated necrosis Activation of receptor-interacting serine/threonine protein (RIP) kinases RIPK1 and RIPK3 coordinate an immunogenic form of programmed cell death known as regulated necrosis or necroptosis (Upton JW et al. 2017). This form of necrosis leads to anti-viral inflammation in host through cell death-associated release of damage-associated molecular patterns (DAMPs) (Nailwal H & Ka-Ming Chan F 2019; Upton JW et al. 2017). Microbial pathogens are able to modulate host regulated necrosis through different triggers and pathways. The promotion and inhibition of host cell death vary and depend on the microbe types, virulence, and phenotypes (Upton JW et al. 2010, 2012, 2017; Jaclyn S Pearson JS et al. 2017; Petrie EJ et al. 2019; Fletcher-Etherington A et al. 2020; Nailwal H & Ka-Ming Chan F 2019; ).
所含基因
9 个基因