与放射冠细胞和透明带相互作用
中文名称
通路描述
典型的哺乳动物卵被约3000个放射冠细胞包围，这些细胞嵌入富含透明质酸的细胞外基质中。建议受精的精子（其顶体完整）穿过放射冠细胞层。透明带（ZP）是包围哺乳动物卵子的糖蛋白基质，在物种特异性的精子-卵子结合、诱导ZP结合精子顶体反应、避免多精受精以及胚胎植入前保护方面发挥重要作用。人类ZP基质由4种糖蛋白组成，分别命名为ZP1、ZP2、ZP3和ZP4。
英文描述
Aberrant regulation of mitotic exit in cancer due to RB1 defects RB1 regulates mitotic exit by acting on SKP2, a component of the SCF E3 ubiquitin ligase complex. RB1 facilitates degradation of SKP2 by the anaphase promoting complex/cyclosome (APC/C), thus preventing SKP2-mediated degradation of the cyclin-dependent kinase inhibitor CDKN1B (p27Kip1). RB1-dependent accumulation of p27Kip1 plays an important role in mitotic exit and RB1-mediated tumor suppression (reviewed by Dyson 2016).
所含基因
19 个基因