CD22介导的BCR调节
中文名称
通路描述
BCR激活受到高度调控，核心受体如CD22（SIGLEC2）设定信号阈值以防止异常免疫反应和自身免疫疾病（Cyster et al. 1997, Han et al. 2005）。CD22是B细胞发育限制阶段表面发现的一种糖蛋白，属于唾液酸结合Ig样 lectin（Siglec）家族，特异性结合许多B细胞糖蛋白上的末端序列N-乙酰神经氨酸α(2-6)半乳糖（NeuAc-alpha(2-6)-Gal）（Powell et al. 1993, Sgroi et al. 1993）。CD22具有七个免疫球蛋白（Ig）样细胞外结构域和胞质尾部，其中包含六个酪氨酸残基，其中三个属于抑制性免疫受体酪氨酸基抑制结构域（ITIMs）序列。当BCR交叉连接时，CD22迅速被酪氨酸激酶Lyn磷酸化，从而招募并激活酪氨酸磷酸酶SHP-1，同时抑制钙信号传导。
英文描述
Maturation of replicase proteins This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
Production of polyprotein fragments (so called replicase proteins) involves the repeated autocleavage of the polyprotein, liberating the two endopeptidases that finally cleave all fragments efficiently. Only nsp3 and nsp4 are post-translationally modified, they are glycosylated (Muramatsu et al, 2015; Harcourt et al, 2004; Oostra et al, 2007).
Production of polyprotein fragments (so called replicase proteins) involves the repeated autocleavage of the polyprotein, liberating the two endopeptidases that finally cleave all fragments efficiently. Only nsp3 and nsp4 are post-translationally modified, they are glycosylated (Muramatsu et al, 2015; Harcourt et al, 2004; Oostra et al, 2007).
所含基因
1 个基因