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Maturation of protein E

Reactome ID: R-HSA-9694493

中文名称

蛋白E成熟

通路描述

该COVID-19通路是通过结合SARS-CoV-1数据(https://reactome.org/documentation/inferred-events)的计算推断和手动校订创建的,如整体SARS-CoV-2感染通路摘要所述。

翻译后,包膜蛋白(E)发生棕榈酰化和泛素化。它们形成三聚体,表现出孔蛋白活性,但不定位到细胞膜(Tan et al, 2004; Liao et al, 2006; Alvarez et al, 2011)
英文描述
Maturation of protein E This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

The envelope protein (E) gets palmitoylated and ubiquitinated after translation. It forms trimers that show porin activity but does not localize to the cell membrane (Tan et al, 2004; Liao et al, 2006; Alvarez et al, 2011)

所含基因

4 个基因