鸟氨酸脱羧酶（ODC）的调节
中文名称
通路描述
多胺增加抗酶（AZ）的产生。抗酶与ODC的羧基末端部分结合，生成无活性的AZ:ODC异二聚体复合物。ODC的羧基末端部分仅在异二聚体中暴露，是后续降解的目标。抗酶中氨基酸末端部分的功能对于ODC的高效蛋白酶体降解至关重要。蛋白酶体循环始于AZ:ODC的切割，将ODC隔离并降解为肽段，同时释放AZ。AZ参与额外的结合和降解循环。抗酶介导的ODC抑制和破坏减少了多胺的合成。此外，抗酶还抑制多胺进入细胞。抗酶的产生减少，完成调节回路（Coffino 2001; Kahana et al. 2005; Murakami et al. 2000; Pegg 2006）。
英文描述
Translation of Structural Proteins This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
Virus mRNA is translated according to the ribosomal scanning model. It is capped and polyadenylated, with regions of nontranslated sequences on both the 5' and 3' ends. Structural proteins are encoded after the polymerase/replicase genes by mRNAs 2 (Spike protein), 3, 4 (Envelope protein), 5 (Membrane protein), and 9. mRNA 3 and 9 are bicistronic, the proteins 3a and 9a (Nucleocapsid protein) having functions in virus assembly and structure. Translation happens in the ER with the exception of 9a which is translated by cytosolic free ribosomes (Fung and Liu, 2019).
Virus mRNA is translated according to the ribosomal scanning model. It is capped and polyadenylated, with regions of nontranslated sequences on both the 5' and 3' ends. Structural proteins are encoded after the polymerase/replicase genes by mRNAs 2 (Spike protein), 3, 4 (Envelope protein), 5 (Membrane protein), and 9. mRNA 3 and 9 are bicistronic, the proteins 3a and 9a (Nucleocapsid protein) having functions in virus assembly and structure. Translation happens in the ER with the exception of 9a which is translated by cytosolic free ribosomes (Fung and Liu, 2019).
所含基因
1 个基因