RND3 GTPase 循环
中文名称
通路描述
RND3（RHOE）是 RND 亚家族中的一种异常 RHO GTPase。RND3 始终结合 GTP 且缺乏 GTPase 活性。没有 GTP 核苷酸交换因子（GEFs）、GTPase 激活蛋白（GAPs）或 GTP 核苷酸解离抑制剂（GDIs）作用于 RND3。RND3 是 ROCK1 激酶活性的直接拮抗剂。RND3 阻止 ROCK1 靶蛋白的磷酸化，类似于 RND1，诱导应力纤维解聚。RND3 调节细胞迁移、神经极性的建立、心脏发育以及妊娠期间子宫肌层的改变。功能缺陷的 RND3 与心肌病、脑积水及癌症相关。与 RND1 类似，RND3 在癌症中既作为抑癌基因又作为原癌基因发挥作用，其对化疗药物的敏感性增加或减少取决于癌症类型和阶段。
英文描述
RND3 GTPase cycle RND3 (RHOE) is an atypical RHO GTPase from the RND subfamily. RND3 is constitutively bound to GTP and lacks GTPase activity. No guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs) or guanine nucleotide dissociation inhibitors (GDIs) act on RND3. RND3 is a direct antagonist of ROCK1 kinase activity. RND3 prevents phosphorylation of ROCK1 targets and, similar to RND1, induces stress fiber disassembly. RND3 regulates cell migration, establishment of neuronal polarity, heart development, and myometrium changes during pregnancy. Defective RND3 function is related to cardiomyopathy, hydrocephalus and cancer. Like RND1, RND3 is implicated both as a tumor suppressor and an oncogene in cancer, and can both increase and decrease sensitivity to chemotherapeutic agents, which depends on cancer type and stage. For review, please refer to Jie et al. 2015 and Paysan et al. 2016.
所含基因
42 个基因