RND2 GTPase 循环
中文名称
通路描述
RND2（RHON）是 RND 亚家族中最少被研究的异常 RHO GTPase。RND2 始终结合 GTP 且缺乏 GTPase 活性。没有 GTP 核苷酸交换因子（GEFs）、GTPase 激活蛋白（GAPs）或 GTP 核苷酸解离抑制剂（GDIs）作用于 RND2。RND2 主要在脑、睾丸和肝脏中表达（Nobes et al. 1998; Nishi et al. 1999）。RND2 调节神经突的生长和分支（Fujita et al. 2002; Kakimoto et al. 2004; Tanaka et al. 2006; Wakita et al. 2011）以及新生神经元在胚胎脑皮层内的迁移（Nakamura et al. 2006; Heng et al. 2008; Alfano et al. 2011; Pacary et al. 2011; Gladwyn-Ng et al. 2015; Heng et al. 2015）。
英文描述
RND2 GTPase cycle RND2 (RHON) is an atypical RHO GTPase and the least studied member of the RND subfamily. RND2 is constitutively bound to GTP and lacks GTPase activity. No guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs) or guanine nucleotide dissociation inhibitors (GDIs) act on RND2. RND2 is predominantly expressed in brain, testis and liver (Nobes et al. 1998; Nishi et al. 1999). RND2 regulates neurite outgrowth and branching (Fujita et al. 2002; Kakimoto et al. 2004; Tanaka et al. 2006; Wakita et al. 2011) and migration of newborn neurons within the embryonic cerebral cortex (Nakamura et al. 2006; Heng et al. 2008; Alfano et al. 2011; Pacary et al. 2011; Gladwyn-Ng et al. 2015; Heng et al. 2015).
所含基因
43 个基因