RND1 GTPase 循环
中文名称
通路描述
RND1 是 RND 亚家族中的一种异常 RHO GTPase。RND1 始终结合 GTP 且缺乏 GTPase 活性。没有 GTP 核苷酸交换因子（GEFs）、GTPase 激活蛋白（GAPs）或 GTP 核苷酸解离抑制剂（GDIs）作用于 RND1。RND1 定位在细胞膜上，但在磷酸化诱导的与 14-3-3 蛋白结合后，可从细胞膜提取并滞留在细胞质中。RND1 拮抗 RHOA，导致肌动蛋白 - 肌球蛋白收缩性降低、应力纤维和粘附斑的丧失，从而产生圆形细胞表型。RND1 在胚胎发育、神经发育、妊娠期间子宫肌层的改变以及血管生成中发挥作用。RND1 在癌症中经常下调，作为抑癌基因发挥作用，但在某些癌症类型中可能发挥原癌基因作用。RND1 的表达对抗癌药物产生反应，可能参与治疗抵抗。
英文描述
RND1 GTPase cycle RND1 is an atypical RHO GTPase from the RND subfamily. RND1 is constitutively bound to GTP and lacks GTPase activity. No guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs) or guanine nucleotide dissociation inhibitors (GDIs) act on RND1. RND1 localizes to the plasma membrane, but can be extracted from the plasma membrane and sequestered to the cytosol upon phosphorylation-induced binding to 14-3-3 protein. RND1 antagonizes RHOA, leading to reduced actomyosin contractility and loss of stress fibers and focal adhesions, which results in a rounded cell phenotype. RND1 plays a role in embryogenesis, neuronal development, myometrium changes during pregnancy, and angiogenesis. RND1 is frequently downregulated in cancer and is implicated as a tumor suppressor, but may play an oncogenic role in some cancer types. RND1 expression increases in response to anti-cancer agents and in may be involved in resistance to treatment. For review, please refer to Mouly et al. 2019.
所含基因
42 个基因